Which DEA form is required when missing controlled substances?

• A. Form 225
• B. Form 106
• C. Form 41
• D. Form 224

Answer: (B)

Missing controlled substances must be reported to the DEA using Form 106. This form is specifically for documenting theft or loss of controlled substances and collects details such as what was missing, where and when the loss occurred, the quantities and drug types involved, and the circumstances. It should be filed as soon as the loss is discovered—typically within one business day—and may prompt local law enforcement involvement and state reporting requirements. Other forms exist for different purposes, such as obtaining or renewing registration to handle controlled substances or for the destruction of substances, but when substances go missing, Form 106 is the correct choice because it is the designated report for theft or loss.