What is the beyond-use date for USP 795 preserved aqueous compounds?

• A. 14 days
• B. 21 days
• C. 60 days
• D. 35 days

Answer: (D)

Beyond-use dating for compounded non-sterile preparations depends on the formulation type and whether an antimicrobial preservative is present. When a water-containing formulation includes a preservative, microbial growth is inhibited, allowing a longer BUD than unpreserved versions. This is why preserved aqueous compounds commonly have a beyond-use date of 35 days. The other timeframes reflect scenarios without preservative or more conservative allowances, so they don’t apply to preserved aqueous formulations. Always check the current USP 795 guidance to confirm the exact BUD for specific preparations and storage conditions.